Genetic Polymorphisms in Xenobiotic Metabolizing Enzymes as a Determinant of Susceptibility to Environmental Mutagens and Carcinogens in Humans
نویسندگان
چکیده
منابع مشابه
Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer.
The variation in individual responses to exogenous agents is exceptionally wide. It is because of this large diversity of responsiveness that risk factors to environmentally induced diseases have been difficult to pinpoint, particularly at low exposure levels. Opportunities now exist for studies of host factors in cancer or other diseases in which an environmental component can be presumed. Man...
متن کاملGenetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity.
Mutagen sensitivity, measuring the extent of chromosome damage induced by an in vitro treatment of peripheral lymphocytes with bleomycin, has been associated with an increased risk of various human cancers. Sensitivity to bleomycin appears to have high heritability and is usually considered to reflect individual capacity to repair DNA lesions. Another potential contributor to variation in bleom...
متن کاملGenetic and Epigenetic Effects of Environmental Mutagens and Carcinogens
1Department of Health Sciences, University of Genoa, Via Antonio Pastore 1, 16132 Genoa, Italy 2Toxicology Institute, Preventive Medical College, Third Military Medical University, Chongqing 400038, China 3Department of Genetics and Evolutionary Biology, Institute of Bioscience, University of São Paulo, 05508-090 São Paulo, SP, Brazil 4Laboratory of Toxicology UT-BIORAD, ENEA, CR Casaccia, Via ...
متن کاملa fundamental study of "histiriographic metafiction", and "literary genres", as introduced in "new historical philosophy", and tracing them in the works of julian barnes.
abstract a fundamental study of “historio-graphic metafiction” and “literary genres”, as introduced in “new historical philosophy”, and tracing them in the works of julian barnes having studied the two novels, the porcupine and arthur & george, by julian barnes, the researcher has applied linda hutcheon’s historio-graphic metafictional theories to them. the thesis is divided into five cha...
15 صفحه اولGenetic polymorphisms in alcohol-metabolizing enzymes and chronic pancreatitis.
AIMS Alcohol misuse is now regarded as an important risk factor for development of chronic pancreatitis (CP). However, not every alcohol misuser develops CP and it therefore might be suggested that susceptibility could be further influenced by inter-individual variations in the activities of alcohol-metabolizing enzymes. Several genetic polymorphisms that may affect the activities of alcohol-me...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1997
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.117.10-11_895